Enum BLQRule 

pub enum BLQRule {
    Zero,
    LoqOver2,
    Exclude,
    Positional,
    TmaxRelative {
        before_tmax_keep: bool,
        after_tmax_keep: bool,
    },
}

BLQ (Below Limit of Quantification) handling rule

Controls how observations marked with Censor::BLOQ are handled during analysis. Applicable to NCA, AUC calculations, and any observation-processing pipeline.

Variants

Zero

Replace BLQ with zero

LoqOver2

Replace BLQ with LOQ/2

Exclude

Exclude BLQ values from analysis

Positional

Position-aware handling (PKNCA default): first=keep(0), middle=drop, last=keep(0)

This is the FDA-recommended approach that:

• Keeps first BLQ (before tfirst) as 0 to anchor the profile start
• Drops middle BLQ (between tfirst and tlast) to avoid deflating AUC
• Keeps last BLQ (at/after tlast) as 0 to define profile end

TmaxRelative

Tmax-relative handling: different rules before vs after Tmax

Contains (before_tmax_rule, after_tmax_rule) where each rule can be:

• “keep” = keep as 0
• “drop” = exclude from analysis Default PKNCA: before.tmax=drop, after.tmax=keep

Fields

before_tmax_keep: bool

Rule for BLQ before Tmax: true=keep as 0, false=drop

after_tmax_keep: bool

Rule for BLQ at or after Tmax: true=keep as 0, false=drop

Trait Implementations

impl Clone for BLQRule

fn clone(&self) -> BLQRule

Returns a duplicate of the value.

fn clone_from(&mut self, source: &Self)

Performs copy-assignment from source.

impl Debug for BLQRule

fn fmt(&self, f: &mut Formatter<'_>) -> Result<(), Error>

Formats the value using the given formatter.

impl Default for BLQRule

fn default() -> BLQRule

Returns the “default value” for a type.

impl<'de> Deserialize<'de> for BLQRule

fn deserialize<__D>( __deserializer: __D, ) -> Result<BLQRule, <__D as Deserializer<'de>>::Error>

where __D: Deserializer<'de>,

Deserialize this value from the given Serde deserializer.

impl PartialEq for BLQRule

fn eq(&self, other: &BLQRule) -> bool

Tests for self and other values to be equal, and is used by ==.

fn ne(&self, other: &Rhs) -> bool

Tests for !=. The default implementation is almost always sufficient, and should not be overridden without very good reason.

impl Serialize for BLQRule

fn serialize<__S>( &self, __serializer: __S, ) -> Result<<__S as Serializer>::Ok, <__S as Serializer>::Error>

where __S: Serializer,

Serialize this value into the given Serde serializer.

impl StructuralPartialEq for BLQRule