Struct DoseRange 

pub struct DoseRange { /* private fields */ }

Allowable dose range constraints

Specifies minimum and maximum allowable doses for optimization. The Nelder-Mead optimizer will search within these bounds via penalty-based constraint enforcement.

Bounds Enforcement

When candidate doses violate the bounds, the cost function returns a large penalty value proportional to the violation distance. This effectively constrains the Nelder-Mead simplex to remain within the valid range.

Examples

use pmcore::bestdose::DoseRange;

// Large range: 0-1000 mg
let range = DoseRange::new(0.0, 1000.0);

// Narrow range: 50-150 mg
let range = DoseRange::new(50.0, 150.0);

// Access bounds
assert_eq!(range.min(), 0.0);
assert_eq!(range.max(), 1000.0);

Clinical Considerations

• Set bounds appropriate for your drug’s clinical use
• Consider patient-specific factors (weight, renal function, etc.)
• If optimization hits a bound, consider widening the range
• Monitor the cost function value - sudden increases may indicate constraint violation
• Default range is [0.0, f64::MAX] (effectively unbounded)

Implementations

impl DoseRange

pub fn new(min: f64, max: f64) -> Self

pub fn min(&self) -> f64

pub fn max(&self) -> f64

Trait Implementations

impl Clone for DoseRange

fn clone(&self) -> DoseRange

Returns a duplicate of the value.

fn clone_from(&mut self, source: &Self)

Performs copy-assignment from source.

impl Debug for DoseRange

fn fmt(&self, f: &mut Formatter<'_>) -> Result

Formats the value using the given formatter.

impl Default for DoseRange

fn default() -> Self

Returns the “default value” for a type.